Translational recoding signals: Expanding the synthetic biology toolbox

  1. Jonathan D. Dinman1
  1. From the Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742
  1. ?1 To whom correspondence should be addressed. Tel.: 301-405-0918; Fax: 301-314-9489; E-mail: dinman{at}umd.edu.
  1. Edited by Ronald C. Wek

Abstract

Innovation follows discovery. If the 20th century was a golden age of discovery in the biomolecular biosciences, the current century may be remembered by the explosion of beneficial devices and therapies conceived by the bioengineers of the era. Much as the development of solid-state electronic components made possible the information revolution, the rational combining of millions of basic molecular control modules will enable the development of highly sophisticated biomachines that will make today's smartphones appear rudimentary. The molecular toolbox is already well-stocked, particularly in our ability to manipulate DNA, control transcription, generate functionally novel hybrid proteins, and expand the genetic code to include unnatural amino acids. This review focuses on how RNA-based regulatory modules that direct alternative readings of the genetic code can be employed as basic circuit components to expand our ability to control gene expression.

Footnotes

  • This work was supported in part by NIGMS, National Institutes of Health, Grants R01 GM117177 and R01 HL119439. The author declares that he has no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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This Article

  1. The Journal of Biological Chemistry 294, 7537-7545.
  1. All Versions of this Article:
    1. REV119.006348v1
    2. 294/19/7537 (most recent)

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