Editors' Picks

Editors’ Picks, formerly called Papers of the Week, represent the top-rated papers published in JBC across the field of biological chemistry, as determined by our Associate Editors, Editorial Board Members and other referees. These articles—essential for any reading list—are accompanied by additional content summarizing the new findings and featuring the scientists involved.

May 24, 2019

Editors' Pick Highlight: A promiscuous kinase inhibitor reveals secrets to cancer cell survival

Paul Shapiro

J. Biol. Chem. 2019 294: 8674. doi:10.1074/jbc.H119.009103

A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers

Suman Rao, Guangyan Du, Marc Hafner, Kartik Subramanian, Peter K. Sorger, and Nathanael S. Gray

J. Biol. Chem. 2019 294: 8664. doi:10.1074/jbc.RA118.006805

May 17, 2019

Editors' Pick Highlight: A chemoprobe tracks its target

Aseem Z. Ansari

J. Biol. Chem. 2019 294: 8323. doi:10.1074/jbc.H119.008945

Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable in vivo pharmacokinetics and pharmacodynamics studies of KDM1A inhibitors

Cristina Mascaró, Alberto Ortega, Elena Carceller, Raquel Ruiz Rodriguez, Filippo Ciceri, Serena Lunardi, Li Yu, Manuel Hilbert, and Tamara Maes

J. Biol. Chem. 2019 294: 8311. doi:10.1074/jbc.RA118.006980

May 10, 2019

Editors' Pick Highlight: Isomerization as the secret Achilles' heel of long-lived proteins

Alex J. Guseman and Angela M. Gronenborn

J. Biol. Chem. 2019 294: 7556. doi:10.1074/jbc.H119.008716

Structural and functional consequences of age-related isomerization in α-crystallins

Yana A. Lyon, Miranda P. Collier, Dylan L. Riggs, Matteo T. Degiacomi, Justin L. P. Benesch, and Ryan R. Julian

J. Biol. Chem. 2019 294: 7546. doi:10.1074/jbc.RA118.007052

May 3, 2019

Editors' Pick Highlight: Unconventional myosins muscle into myofibrils

Elizabeth J. Luna

J. Biol. Chem. 2019 294: 7219. doi:10.1074/jbc.H119.008784

A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart

Markus Horsthemke, Lauryl M. J. Nutter, Anne C. Bachg, Boris V. Skryabin, Ulrike Honnert, Thomas Zobel, Sven Bogdan, Monika Stoll, Matthias D. Seidl, Frank U. Müller, Ursula Ravens, Andreas Unger, Wolfgang A. Linke, Pim R. R. van Gorp, Antoine A. F. de Vries, Martin B?hler, and Peter J. Hanley

J. Biol. Chem. 2019 294: 7202. doi:10.1074/jbc.RA118.004560

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