Virtual Issue: Focus on South America

Virtual Issue: Focus on South America

There are few journals that can appreciate tradition like JBC, so reading the welcome letter from the president and vice president of the Brazilian Society of Biochemistry and Molecular Biology describing their annual meeting as “one of the most traditional events in the Brazilian scientific community” warms our 114-year old heart. In honor of this conference’s storied past and the vibrant research future of the attendees, we’ve collected a snapshot of the scientific present in this virtual issue: recent papers from authors in Brazil, Argentina, Uruguay, Colombia and Chile. The conference, held May 14-17, 2019, tackles a multitude of timely themes, some of which are captured below. We’ve made these articles free to all; download and read them today!


The cover art shows a surface representation of the translocase outer membrane complex component Tom70, which binds to the chaperone Hsp90 as part of preprotein import into the mitochondria and which happens to look a bit like the South American continent. The specific interaction sites between the two proteins was explored by Zanphorlin et al. Artwork created by EJ Marklin.

Redox processes

Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites
Bruno Manta, Matías N. M?ller, Mariana Bonilla, Matías Deambrosi, Karin Grunberg, Massimo Bellanda, Marcelo A. Comini and Gerardo Ferrer-Sueta
First published on December 28, 2018

The redox-sensing gene Nrf2 affects intestinal homeostasis, insecticide resistance, and Zika virus susceptibility in the mosquito Aedes aegypti
Vanessa Bottino-Rojas, Octavio A. C. Talyuli, Luana Carrara, Ademir J. Martins, Anthony A. James, Pedro L. Oliveira and Gabriela O. Paiva-Silva
First published on April 23, 2018

The labile iron pool attenuates peroxynitrite-dependent damage and can no longer be considered solely a pro-oxidative cellular iron source
Fernando Cruvinel Damasceno, André Luis Condeles, Angélica Kodama Bueno Lopes, R?mulo Rodrigues Facci, Edlaine Linares, Daniela Ramos Truzzi, Ohara Augusto and José Carlos Toledo Jr.
First published on April 16, 2018

Peroxynitrite preferentially oxidizes the dithiol redox motifs of protein-disulfide isomerase
álbert Souza Peixoto, R. Ryan Geyer, Asif Iqbal, Daniela R. Truzzi, Ana I. Soares Moretti, Francisco R. M. Laurindo and Ohara Augusto
First published on November 30, 2017

Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2
Larissa A. C. Carvalho, Daniela R. Truzzi, Thamiris S. Fallani, Simone V. Alves, José Carlos Toledo, Ohara Augusto, Luís E. S. Netto and Flavia C. Meotti
First published on March 27, 2017

The chemical basis of thiol addition to nitro-conjugated linoleic acid, a protective cell-signaling lipid
Lucía Turell, Darío A. Vitturi, E. Laura Coiti?o, Lourdes Lebrato, Matías N. M?ller, Camila Sagasti, Sonia R. Salvatore, Steven R. Woodcock, Beatriz Alvarez and Francisco J. Schopfer
First published on December 6, 2016

Heat shock protein 90 kDa (Hsp90) has a second functional interaction site with the mitochondrial import receptor Tom70
Leticia M. Zanphorlin, Tatiani B. Lima, Michael J. Wong, Tiago S. Balbuena, Concei??o A. S. A. Minetti, David P. Remeta, Jason C. Young, Leandro R. S. Barbosa, Fabio C. Gozzo and Carlos H. I. Ramos
First published on July 8, 2016

When the good and the bad make the ugly: The discovery of peroxynitrite
Rajendrani Mukhopadhyay
First published on December 25, 2015

Advances in glycobiology

Biosynthesis of O-N-acetylgalactosamine glycans in the human cell nucleus
Romina B. Cejas, Virginia Lorenz, Yohana C. Garay and Fernando J. Irazoqui
First published on December 27, 2018

Abrogation of glucosidase I–mediated glycoprotein deglucosylation results in a sick phenotype in fission yeasts: Model for the human MOGS-CDG disorder
Giovanna L. Gallo, Ayelén Valko, Sofía I. Aramburu, Emiliana Etchegaray, Christof V?lker, Armando J. Parodi and Cecilia D'Alessio
First published on November 2, 2018

Structural basis of exo-β-mannanase activity in the GH2 family
Mariane Noronha Domingues, Flavio Henrique Moreira Souza, Plínio Salmazo Vieira, Mariana Abrah?o Bueno de Morais, Letícia Maria Zanphorlin, Camila Ramos dos Santos, Renan Augusto Siqueira Pirolla, Rodrigo Vargas Honorato, Paulo Sergio Lopes de Oliveira, Fabio Cesar Gozzo and Mário Tyago Murakami
First published on July 11, 2018

O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats
Rodrigo Pacheco Silva-Aguiar, Nathália C. F. Bezerra, Miguel C. Lucena, Gabriela M. Sirtoli, Roberto T. Sudo, Gisele Zapata-Sudo, Christina M. Takiya, Ana Acacia S. Pinheiro, Wagner Barbosa Dias and Celso Caruso-Neves
First published on June 28, 2018

A novel carbohydrate-binding module from sugar cane soil metagenome featuring unique structural and carbohydrate affinity properties
Bruna Medeia Campos, Marcelo Vizona Liberato, Thabata Maria Alvarez, Letícia Maria Zanphorlin, Gabriela Cristina Ematsu, Hernane Barud, Igor Polikarpov, Roberto Ruller, Harry J. Gilbert, Ana Carolina de Mattos Zeri and Fabio Marcio Squina
First published on September 12, 2016

Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation
Miguel C. Lucena, Patricia Carvalho-Cruz, Joana L. Donadio, Isadora A. Oliveira, Rafaela M. de Queiroz, Monica M. Marinho-Carvalho, Mauro Sola-Penna, Iron F. de Paula, Katia C. Gondim, Mark E. McComb, Catherine E. Costello, Stephen A. Whelan, Adriane R. Todeschini and Wagner B. Dias
First published on April 18, 2016

Microbiology and parasites

Kinetics and structural features of dimeric glutamine-dependent bacterial NAD+ synthetases suggest evolutionary adaptation to available metabolites
Adrian Richard Schenberger Santos, Edileusa Cristina Marques Gerhardt, Vivian Rotuno Moure, Fábio Oliveira Pedrosa, Emanuel Maltempi Souza, Riccardo Diamanti, Martin H?gbom and Luciano Fernandes Huergo
First published on March 26, 2018

Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases
Víctor Castro-Fernandez, Alejandra Herrera-Morande, Ricardo Zamora, Felipe Merino, Felipe Gonzalez-Ordenes, Felipe Padilla-Salinas, Humberto M. Pereira, Jose Brand?o-Neto, Richard C. Garratt and Victoria Guixe
First published on July 18, 2017

Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection
Luis H. Franco, Anna K. A. Fleuri, Natália C. Pellison, Gustavo F. S. Quirino, Catarina V. Horta, Renan V. H. de Carvalho, Sérgio C. Oliveira and Dario S. Zamboni
First published on June 12, 2017

Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae
Fernando A. Gonzales-Zubiate, Ellen K. Okuda, Julia P. C. Da Cunha and Carla Columbano Oliveira
First published on May 24, 2017

Filaments and fingers: Novel structural aspects of the single septin from Chlamydomonas reinhardtii
Andressa P. A. Pinto, Humberto M. Pereira, Ana E. Zeraik, Heloisa Ciol, Frederico M. Ferreira, José Brand?o-Neto, Ricardo DeMarco, Marcos V. A. S. Navarro, Cristina Risi, Vitold E. Galkin, Richard C. Garratt and Ana P. U. Araujo
First published on May 5, 2017

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes
María Julia Barisón, Ludmila Nakamura Rapado, Emilio F. Merino, Elizabeth Mieko Furusho Pral, Brian Suarez Mantilla, Letícia Marchese, Cristina Nowicki, Ariel Mariano Silber and Maria Belen Cassera
First published on March 29, 2017

Functional validation of ABCA3 as a miltefosine transporter in human macrophages: Impact on intracellular survival of Leishmania (Viannia) panamensis
Luuk C. T. Dohmen, Adriana Navas, Deninson Alejandro Vargas, David J. Gregory, Anke Kip, Thomas P. C. Dorlo and Maria Adelaida Gomez
First published on February 22, 2016

Neurobiology and neurodegeneration

Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment
Juciano Gasparotto, Carolina S. Girardi, Nauana Somensi, Camila T. Ribeiro, José C. F. Moreira, Monique Michels, Beatriz Sonai, Mariane Rocha, Amanda V. Steckert, Tatiana Barichello, Jo?o Quevedo, Felipe Dal-Pizzol and Daniel P. Gelain
First published on November 10, 2017

Nanomolar nitric oxide concentrations quickly and reversibly modulate astrocytic energy metabolism
Alejandro San Martín, Robinson Arce-Molina, Alex Galaz, Gustavo Pérez-Guerra and L. Felipe Barros
First published on March 24, 2017

Read the accompanying Highlight by Bak

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice
Jordano Brito-Moreira, Mychael V. Lourenco, Mauricio M. Oliveira, Felipe C. Ribeiro, José Henrique Ledo, Luan P. Diniz, Juliana F. S. Vital, Margaret H. Magdesian, Helen M. Melo, Fernanda Barros-Arag?o, Jorge M. de Souza, Soniza V. Alves-Leon, Flavia C. A. Gomes, Julia R. Clarke, Cláudia P. Figueiredo, Fernanda G. De Felice and Sergio T. Ferreira
First published on March 10, 2017

Activation of Wnt signaling in cortical neurons enhances glucose utilization through glycolysis
Pedro Cisternas, Paulina Salazar, Carmen Silva-álvarez, L. Felipe Barros and Nibaldo C. Inestrosa
First published on October 4, 2016

Subversion of Schwann cell glucose metabolism by Mycobacterium leprae
Rychelle Clayde Affonso Medeiros, Karina do Carmo de Vasconcelos Girardi, Fernanda Karlla Luz Cardoso, Bruno de Siqueira Mietto, Thiago Gomes de Toledo Pinto, Lilian Sales Gomez, Luciana Silva Rodrigues, Mariana Gandini, Julio Jablonski Amaral, Sérgio Luiz Gomes Antunes, Suzana Corte-Real, Patricia Sammarco Rosa, Maria Cristina Vidal Pessolani, José Augusto da Costa Nery, Euzenir Nunes Sarno, Leonardo Ribeiro Batista-Silva, Mauro Sola-Penna, Marcus Fernandes Oliveira, Milton Ozório Moraes and Flavio Alves Lara
First published on August 23, 2016

Other diseases and disorders

Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells
Nataly Melo dos Santos, Guilherme A. P. de Oliveira, Murilo Ramos Rocha, Murilo M. Pedrote, Giulia Diniz da Silva Ferretti, Luciana Pereira Rangel, José A. Morgado-Diaz, Jerson L. Silva and Etel Rodrigues Pereira Gimba
First published on April 26, 2019

Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation
Vanessa C. Fernandes, Volha A. Golubeva, Giuliano Di Pietro, Cara Shields, Kwabena Amankwah, Thales C. Nepomuceno, Giuliana de Gregoriis, Renata B. V. Abreu, Carly Harro, Thiago T. Gomes, Ricceli F. Silva, Guilherme Suarez-Kurtz, Fergus J. Couch, Edwin S. Iversen, Alvaro N. A. Monteiro and Marcelo A. Carvalho
First published on February 14, 2019

Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor
Carla Borini Etichetti, Carolina Di Benedetto, Carolina Rossi, María Virginia Baglioni, Silvio Bicciato, Giannino Del Sal, Mauricio Menacho-Marquez and Javier Girardini
First published on January 17, 2019

A human-specific, truncated α7 nicotinic receptor subunit assembles with full-length α7 and forms functional receptors with different stoichiometries
Matías Lasala, Jeremías Corradi, Ariana Bruzzone, María del Carmen Esandi and Cecilia Bouzat
First published on May 21, 2018

The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats
Camila Cristina Pasquali, Zeyaul Islam, Douglas Adamoski, Igor Monteze Ferreira, Ricardo Diogo Righeto, Jefferson Bettini, Rodrigo Villares Portugal, Wyatt Wai-yin Yue, Ana Gonzalez, Sandra Martha Gomes Dias and Andre Luis Berteli Ambrosio
First published on May 19, 2017

Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain
Petar Stefanov Kovachev, Debapriya Banerjee, Luciana Pereira Rangel, Jonny Eriksson, Murilo M. Pedrote, Mafalda Maria D. C. Martins-Dinis, Katarina Edwards, Yraima Cordeiro, Jerson L. Silva and Suparna Sanyal
First published on April 18, 2017

Allosteric transmission along a loosely structured backbone allows a cardiac troponin C mutant to function with only one Ca2+ ion
Mayra de A. Marques, Jose Renato Pinto, Adolfo H. Moraes, Anwar Iqbal, Mariana T. Q. de Magalh?es, Jamila Monteiro, Murilo M. Pedrote, Martha M. Sorenson, Jerson L. Silva and Guilherme A. P. de Oliveira
First published on January 3, 2017

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